| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3f41a73d38ae52429179c390467b8c94 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 |
| filingDate |
2000-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24dc1f0e69e3aa1b18ab6b7b51342640
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b90cc5e5a4e9128267370bbe2d35a0fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e7dd0942552641c66f82cdd8bb50bc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19d565094cc8e871d8ae85b5cb0607d8 |
| publicationDate |
2001-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0102031-A2 |
| titleOfInvention |
Targeted anticalcification treatment |
| abstract |
Methods for providing biomaterials with increased resistance to calcification by treating with cell-targeted agents and/or with matrix-targeted agents. Cell-targeted agents are used which block calcium channels or which prevent oxidative damage to cells and/or inhibit enzymes. Other treatments of biomaterials may remove cell-derived calcium-binding components or target extracellular matrices, as by cleaving proteins with cyanogen bromide or reducing disulfide bonds to produce sulfhydryl groups which are thereafter alkylated. Combinations of the foregoing different treatments are also effective in increasing the calcification resistance of cardiovascular tissues that were previously subjected to chemical fixing and/or other anticalcification treatments. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7955788-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2597564-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9737400-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973632-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11395726-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9610158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7078163-B2 |
| priorityDate |
1999-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |