| abstract |
Substituted 5-aryl-2,4-thiazolidinediones (I) are useful in the treatment, control, and prevention of diabetes and diseases and conditions that commonly occur with diabetes, including hyperglycemia, hyperlipidemia, atherosclerosis, obesity, vascular restenosis, and others. The compound 5-[3-(3-(2-propyl-4-phenoxyphenoxy)propoxy)phenyl]-2,4-thiazolidinedione having the x-ray powder diffraction of Table 1 is particularly suitable for this use. The process for making substituted 5-aryl-2,4-thiazolidinediones and 5-[3-(3-(2-propyl-4-phenoxyphenoxy)propoxy)phenyl]-2,4-thiazolidinedione has been improved. (Formula I); n = 0 to 3; X, Y, Ar?1 and Ar2¿ are as in the application. |