| abstract |
Optically active pyrrolopyridazine compounds having the general formula (I) or pharmacologically acceptable salts thereof: (wherein R1 is alkyl; R?2 and R3¿ are each independently alkyl; R4 is optionally substituted aryl; and A is imino, oxygen, or sulfur). The compounds and the salts exhibit an excellent inhibitory activity against the secretion of gastric hydrochloric acid, a protective activity for the gastric mucus, and an excellent antimicrobial activity against Helicobacter pylori, and are useful as drugs, particularly preventive or therapeutic agents for ulcerative diseases. |