abstract |
Crystals of mono- or tri-hydrates of hydrochlorides of carbapenem compounds useful as antibacterial agents, which are chemically stable and easy to purify; processes for the production of the crystals; and injectable powder preparations manufactured by packing the same. Specifically, crystals of monohydrates of hydrochlorides of carbapenem compounds which have powder X-ray diffraction patterns containing spacings (d) of 5.2, 4.3 and 4.0 Å and crystals of trihydrates of hydrochlorides of carbapenem compounds which have X-ray diffraction patterns containing spacings (d) of 9.0, 4.1 and 2.8 Å; processes for the production of the crystals; and injectable powder preparations manufactured by packing the same. |