| abstract |
The present invention provides a series of compounds having structural formulas (I), (II), (III), (IV) wherein n1 is 1 to 5, n2 is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein R' is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n1 is not 1; and wherein X and R' are independently optionally substituted at C2, C3 or C4 in compounds of Formula (IV) or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in an individual. |