| abstract |
The present invention provides methods of identifying candidate agents that bind to and regulate cellular proteins involved in multi-drug resistance (MDR). As outlined herein, there are two basic types of screens that can be done: 1) screens for compounds that confer a multridrug resistance phenotype; and, 2) screens for compounds that ameliorate a multridrug resistance phenotype. Once target molecules have been identified, as is outlined herein with the identification of XAPC7 and Zeta, and, when inhibited by the RGP8.5 peptide confer multidrug resistance, the XAPC7 and Zeta molecules can be used in screens for candidate drugs that bind to them and modulate their activity. |