http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0071542-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2932d11b67f7af2691ef97e70b8d7bc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-10 |
| filingDate | 2000-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_263e589f5627c82ee8a78197a62c6b9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3dd4936de053626d74eb67338ee5e34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_007ac0feb7fb5fbe9c2ea6744dd9984e |
| publicationDate | 2000-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0071542-A1 |
| titleOfInvention | Improved synthesis of a tetraamido macrocycle ligand |
| abstract | A synthesis for preparing a tetraamido-macrocyclic ligand, such as 5,6-Benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane, H4, in greatly improved yield and in a commercially viable manner, comprising the steps of dissolving a quantity of a 1,2-bis(2-aminoalkanamido)benzene in a solution comprised of methylene chloride and ethyl acetate to yield a first reaction solution; dissolving a quantity of a malonyl dihalide in an ethyl acetate solution to yield a second reaction solution; adding the first reaction solution and the second reaction solution to a reaction vessel containing a third reaction solution comprised of refluxing ethyl acetate solution and an acid scavenger to form a reaction mixture; and isolating a solid product comprised of the tetraamido-macrocycle directly from the reaction mixture by filtration. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004076425-A1 |
| priorityDate | 1999-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.