| abstract |
The invention relates to isolated nucleic acid molecules, named TANGO 204, TANGO 206, TANGO 209, and A236, which encode fully secreted proteins associated with the membrane. The invention also relates to antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and transgenic animals into which a nucleic acid molecule according to the invention has been introduced or interrupted. The invention further relates to isolated polypeptides, fusion polypeptides, peptides and antigenic antibodies. Finally, the invention relates to diagnostic, screening and therapy methods which rely on the use of the compositions of the invention. |