| abstract |
The invention relates to novel 1-(p-thienylbenzyl)-imidazoles of formula (I), wherein radicals R(1)-R(6), X and Y have the meaning cited in the description. Said compounds are potent agonists of angiotensin-(1-7) receptors. As a result of the production and release of vasodilating, antithrombotic and cardioprotective messengers such as cyclic 3',5'-guanosine monophosphate (cGMP) and nitrogen monoxide (NO) associated with the stimulation of said receptors in the endothelial cells, said compounds represent valuable medicaments in the treatment and prophylaxis of hypertension, heart hypertrophy, heart failure, coronary heart diseases such as Angina Pectoris, myocardial infarct, vascular restenosis following angioplasty, cardiomyopathy, endothelial dysfunction or endothelial lesions, e.g. as a result of atherosclerotic processes or in case of Diabetis mellitus and arterial or venous thrombosis. |