http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0066721-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1370e26883b73d6747930ad72dac90f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa84e6c0596c88b3ed7d443c075c483e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7aa001f3235c07b0298867908d45e21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb18a09d5f5cefed4e91eb07d2e42aa8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eec449805da81da833eb468d329625f4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 |
| filingDate | 2000-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06bfc0136b73bc55b6e515745aa90bd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d35e7352cff6409bcdddc88d61b519f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97c98efcb6155ad51dcf407f2719e83a |
| publicationDate | 2000-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0066721-A2 |
| titleOfInvention | Decreasing adipose mass by altering rsk2 activity |
| abstract | Deletion of the rsk2 gene in mice results in reduced body weight, reduced body fat and reduced sensitivity to diet-induced weight gain, as well as lower levels of leptin in the serum of rsk2 deficient mice and lower levels of oxygen consumption, as compared to wild type littermates. Thus, altering RSK2 activity provides a means for modulating RSK2-mediated signaling and therefore modulating the above described physiological parameters. The present invention encompasses methods and compositions for altering, or modulating in a mammal, body weight, fat content, leptin levels by altering, or modulating, RSK2 activity. Specifically encompassed in the present invention are methods and compositions to alter activity of the RSK2. The present invention is drawn to a model for the study of Coffin-Lowry syndrome as well as an in vivo model to screen and test therapeutic agents for the treatment of Coffin-Lowry syndrome. The present invention is further drawn to use of the rsk2 knockout mouse as a model to study and treatment of lipodystrophy and impaired glucose tolerance in mammals. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004035815-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011055366-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03105766-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03105766-A3 |
| priorityDate | 1999-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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