| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5961e579b3eeb92b8e6975825aa2d619
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52e76849024c255a4c0b2c93b2e3d9a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_058609ebf0bf14c6f5eb39ad4e3cc16c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-405 |
| filingDate |
2000-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34e2348416fdd3c4255fae9ab00b9af0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d7690a5daeba5cdc1d664483a12736a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93e7f337ab572d74ad9570cd8cb79721 |
| publicationDate |
2000-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0062775-A1 |
| titleOfInvention |
Compositions and methods for increasing the bioavailability of lactone ring containing drugs |
| abstract |
Compositions and methods are described for increasing the bioavailability of drugs, and in particular, drugs and prodrugs containing lactone structures which are hydrolyzed to open forms (carboxylic acids and alcohols) by serum and tissue paraoxonase. Inhibitors of paraoxonase (e.g. lactams) are co-administered with such drugs, thereby preventing paraoxonase from acting on these lactone substrates. Such inhibitors are particularly suitable in conjunction with the administration of lovastatin, simvastatin or mevastatin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03007993-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0190336-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0190336-A2 |
| priorityDate |
1999-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |