| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08528f49dabdd8210791e6bc00d95b56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21cfa582a923fd1cbb49aa18c68db60e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-811 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31 |
| filingDate |
2000-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d14816cb2bc3d180258a6fc6ee89803e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_805853e098fce7b0f80106e07f173192 |
| publicationDate |
2000-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0061634-A2 |
| titleOfInvention |
Ecotin-variant modulators of serine proteases |
| abstract |
This invention provides a class binding proteins that specifically bind to polypeptides having a chymotrypsin fold (e.g. serine proteases). When the target polypeptides are serine proteases the binding proteins can act to inhibit or activate the serine protease. The binding proteins are based on the structure of ecotin. It was discovered that modification of the amino or carboxyl terminus and/or randomization of one or more of loops 50s, 60s, 80s or 100s will provide an ecotin variant library from which can be selected binding molecules (e.g. protease modulators) specific to virtually any serine protease. Depending on the ecotin variant and the target serine protease, the modulator can act as a serine protease inhibitor or as a serine protease activator. Specific agonists of Factor IXa are disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006044650-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008517275-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106226428-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106226428-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107135653-A |
| priorityDate |
1999-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |