| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8381805eba6d034fc77bd230dd02e6e2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-10043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate |
2000-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adb148279d3def3fbe5f8f2b7c821231
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9b275fdce12c89a9e244a514defb7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba9f6610d16f65280948c17ae55e871d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0682a48dcd684d91d8d8884c67484255 |
| publicationDate |
2000-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0056874-A1 |
| titleOfInvention |
Retroviral vectors and methods for production and use thereof |
| abstract |
The invention features methods and reagents for introducing a mutation into a gene in a cell. The method includes contacting the cell with a recombinant retrovirus including: (i) branch-point sequence; (ii) a polypyrimidine tract; (iii) a splice acceptor; (iv) a splice donor; and (v) viral long-terminal repeats, wherein the splice acceptor and the splice donor flank nucleic acid sequence encoding a stop codon that is in frame with the splice acceptor; and allowing the retrovirus to integrate into a gene of the cell. Integration of the retrovirus into the gene introduces a mutation into the gene. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1268767-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6897020-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7625755-B2 |
| priorityDate |
1999-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |