| abstract |
The present invention relates to diaryl thioethers, including substituted diphenyl thioethers. Furthermore, the present invention relates to the use of the aforementioned compounds as ligands for cellular receptors, including adenosine and G-protein-coupled receptors. In certain embodiments, the compounds of the present invention are selective ligands, e.g., antagonists or agonists, for a particular family or subtype of adenosine or G-protein-coupled receptor. Additionally, the present invention relates to pharmaceutical preparations comprising the ligands, and their use as medicaments in the treatment of diseases deriving, at least in part, from cellular pathways incorporating adenosine or G-protein-coupled receptors. |