| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7eb4095c6148d001295d350626f18a0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d81c8f6ab176a40bd8b8ac74a9f7372c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e25db59d1d5258f0d0420d699ac453d8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 |
| filingDate |
2000-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76e01dd94e5f0efc31440affe1985dd2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f03a47bbf6aad99f5404700a89f231cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_248507fb8cb366d00e6b0c07253e8947 |
| publicationDate |
2000-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0055344-A1 |
| titleOfInvention |
Adenoviral vector expressing a sv40 t antigen antisense rna |
| abstract |
The present invention provides a replication-deficient recombinant adenovirus comprising the nucleic acid that encodes an antisense ribonucleic acid to the SV40 T antigen. The invention also provides replication-deficient recombinant adenovirus comprising the nucleic acid that encodes an antisense ribonucleic acid to the SV40 T early region. Also provided is a method of treating cancer by administering a replication-deficient recombinant adenovirus comprising a nucleic acid that encodes an antisense ribonucleic acid to the SV40 T antigen. Further provided are methods. Further provided are methods of inducing apoptosis, effecting cell growth arrest, reducing the levels of expression of proto-oncogenes, upregulating pro-apoptotic proteins, maintaining normal levels of functional p53 and, maintaining functional levels of Rb, p107, and p 130 by administering a replication-deficient recombinant adenovirus comprising a nucleic acid that encodes an antisense ribonucleic acid to the SV40 T antigen. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012143427-A1 |
| priorityDate |
1999-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |