| abstract |
This invention relates to newly identified breast, ovarian, breast cancer and/or ovarian cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'breast/ovarian cancer antigens', and to the complete gene sequences associated therewith and to the expression products thereof, as well as the use of such breast/ovarian cancer antigens for detection, prevention and treatment of disorders of the female reproductive system, particularly disorders of the breast and/or ovary, including the presence of breast cancer and/or ovarian cancer. This invention relates to the breast/ovarian cancer antigens as well as vectors, host cells, antibodies directed to breast/ovarian cancer antigens and recombinant and synthetic methods for producing the same. Also provided are diagnostic methods for diagnosing and treating, preventing and/or prognosing disorders related to the female reproductive system, particularly disorders of the breast and/or ovary, including breast cancer and/or ovarian cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of breast/ovarian cancer antigens of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and/or function of the polypeptides of the present invention. |