| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efc8a01a30d9550b85524291e7c5d0ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7826e82a59639f553bfb024dfb2a0ea5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f6f2929898a5c7177d2d7d539a2662c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a54b0781f1b027e0be75aaa9b6996591
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e3c87c4fb44854b8532be8f7c62175b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 |
| filingDate |
2000-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_902b951a3639a6448eb368ab697090cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36e477ce7af8ddc074bed37dce323a72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19a33a890f2f00d5086289fef28b1b89 |
| publicationDate |
2000-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0053569-A1 |
| titleOfInvention |
Method for preparing 2-2[(4-alkylphenyl)-ethyl]-2-amino-propanediol and intermediates useful in such preparation |
| abstract |
This invention relates to a method for preparing 2-2[(4-alkylphenyl)-ethyl]-2-amino-propanediol compounds of general formula (I), wherein R is C1-10 alkyl, preferably n-octyl, which comprises the following steps: reacting alkylbenzene (II) with acetyl chloride in the presence of Lewis acid; preparing p-alkyl α-halophenylethyl ketone (IV) according to a conventional method in the presence of a small amount of Lewis acid; condensing the obtained compound (IV) with 2-acylamino-malonate to give 2-acylamino-2-[2-p-alkylphenyl-2-oxo-ethyl]-malonate (VI) in the presence of a base; reducing product (VI) to 2-acylamino-2-[2-p-alkylphenyl-2-hydroxy-ethyl]-propanediol (VII); then hydrolyzing and hydrogenating compound (VII) to form compound (I). This invention also relates to the intermediates involved in the above method. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7910617-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014111949-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8101650-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8809571-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9133096-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012056458-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012508216-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8735627-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067396-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014139179-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016028056-A |
| priorityDate |
1999-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |