| abstract |
Compositions for transdermal and dermal administration of pharmaceutically active principles, particularly steroids, as for example estrogens, steroidal progestins or anti-progestins, and non steroidal anti-inflammatory drugs (FANS), as for example, diclofenac, ammonium diethyl diclofenac, ketoprofen, piroxicam, nimesulide, wherein the natural essence known as niaouli oil, as enhancer of the percutaneous permeation and absorption of the drug, is included. In addition to the absorption of the drugs at systemic level the formulations containing niaouli oil are suitable for dermatological applications wherein an improved penetration of a drug, for example a steroidal or nonsteroidal anti-inflammatory drug, through the horny layer is required. The invention further relates to therapeutic systems for the transdermal administration (STT) including niaouli essential oil as a penetration enhancer. |