http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0052457-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4438bb508d1d4dd44aead423b6dc7b0b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5438 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 |
| filingDate | 2000-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c9140a82515439f7d7cad0d30a8f824 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4621c109c96a709a0ee1d1d4ad0806f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad940f65fb27ff676ad93440fc0cfd3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91ce57dbe0df0dda7d608fe9307a4698 |
| publicationDate | 2000-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0052457-A1 |
| titleOfInvention | Card-based biosensor device |
| abstract | A diagnostic card device for use in detecting or quantitating an analyte present in a liquid sample, comprising a card substrate having a sample introduction region, a biosensor, and a sample-flow pathway communicating between the sample-introduction region and the biosensor, circuitry for generating an analyte-dependent electrical signal from the biosensor; and a signal-responsive element for recording such signal. In one embodiment, the biosensor includes a detection surface with surface-bound molecules of a first charged, coil-forming peptide capable of interacting with a second, oppositely charged coil-forming peptide to form a stable α-helical coiled-coil heterodimer, where the binding of the second peptide to the first peptide, to form such heterodimer, is effective to measurably alter a signal generated by the biosensor. The sample-flow pathway contains diffusibly bound conjugate of the second coil-forming peptide and the analyte (or an analyte analog) and immobilized analyte-binding agent. The analyte in the liquid sample and the conjugate compete for binding with the immobilized analyte-binding agent. Unbound conjugate migrates by capillarity to the biosensor. Liquid sample containing conjugate migrates in the sample flow pathway by capillary action or is driven by a micropump. In another embodiment, the biosensor includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having analyte-binding agent attached to the exposed monolayer surface. Binding of analyte to the monolayer-bound analyte-binding agent, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02073153-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02073153-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10111457-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10111458-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10111457-B4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10111458-B4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011158246-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2261663-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10073107-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10184946-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8597574-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9110044-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE45764-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107389752-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03059954-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03059954-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10816563-B2 |
| priorityDate | 1999-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.