| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7ea548a2c29031cf77552d41baa7ed8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fb653c819e697e4791f516317a5756a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00533291e0dc38cee705b60b81ac6083 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-22 |
| filingDate |
2000-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec807b5db3e83d0e0678966ac71ee194
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a24662055a4848cabf9b6b8bfa88945
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_941aebfcd838dc9f8ed85ea4c0cd9988 |
| publicationDate |
2002-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0052185-A9 |
| titleOfInvention |
Application of dna vectors for the treatment of viral infection |
| abstract |
The present invention relates to DNA-based constructs and methods for treating viral infections. In a preferred embodiment, an HSV based amplicon is topically applied to the site of an actively replicating HSV infection, initiating a four-tier anti-viral therapy. First, IFN-η expression from a constitutive promoter exerts an antiviral effect at the site of active infection. Second, replication machineray of the resident virus packages the amplicon into HSV virions, in situ, thereby decreasing the infectious titer. Third, HSV virion containing amplicon DNA are transported into the nervous system where IFN-η expression promotes the establishment of latency. Fourth, as the host is exposed to emotional or physical stressor that reactivate the virus, amplicon-directed IFN-η is expressed. Increasing titers of IFN-η enforce viral latency. |
| priorityDate |
1999-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |