| abstract |
Vascular damaging agents for use in treating diseases involving angiogenesis are provided which are compounds of formula: A-X-B, wherein A is a substituted cis-stilbene moiety, X a linker bond, atom or group and B is a moiety derived from an inhibitor of the formation or action of nitric oxide in mammalian systems specifically an inhibitor of nitric oxide synthase, and hydrates, pharmaceutically acceptable salts and prodrugs thereof. There are also provided compositions containing such compounds. |