| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a9f38480af729f55129e3a9318d2c91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec3d7a9a543c4214ef75cdabb2d0e04b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b658a57d016b2ea7eff723ae9856fd06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ab14228dab634a33699c5f38c3a78c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_863f0e0055233609e9f873e3a9e68f7d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
2000-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ce2cd7ccad3a4957157faff269ff453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5db32da6bd1bd595ff158f9213827ce8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a62c83325297e43bcbe3a6190446d43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97b72876473841281a1afbc5555b6a8c |
| publicationDate |
2001-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0047760-A9 |
| titleOfInvention |
Atm kinase modulation for screening and therapies |
| abstract |
The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assay system is adaptable to screening for ATM modulators, particularly inhibitors. In a specific embodiment, the substrate recognition sequence and mutagenized variants of this sequence were incorporated in a GST fusion protein and assayed for phosphorylation by ATM kinase. This assay system is useful in screening for ATM inhibitors. ATM function assays were validated using an ATM-kinase dead dominant-negative mutant. |
| priorityDate |
1999-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |