Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcf7b7d790f985572f4c8c147f175b56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_baaef8c0df688684a03d303fd4ffc6f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab9c317c3f11e59eebed90313359215a |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
filingDate |
2000-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f700b35e412084b2f2363fde2b3d5f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_319db311e54b8fb7829b9ef31acf13b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4fa1767851b8cb81889fa0548e5c3e3 |
publicationDate |
2000-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-0047735-A2 |
titleOfInvention |
NON-HUMAN TRANSGENIC ANIMAL WHOSE GERM CELLS AND SOMATIC CELLS CONTAIN A KNOCKOUT MUTATION IN DNA ENCODING ORPHAN NUCLEAR RECEPTOR ERRalpha |
abstract |
The present invention relates to a transgenic non-human mammal whose germ cells and somatic cells contain a knockout mutation in DNA encoding orphan nuclear receptor ERRα. More specifically, the invention relates to knockout mice whose germ cells and somatic cells contain a knockout mutation in DNA encoding orphan nuclear receptor ERRα. The invention further relates to such knockout non-human mammals which express an ERRα gene which is different from the endogenous gene which was disrupted. In a particular embodiment, the invention relates to a transgenic mouse having its endogenous ERRα gene disrupted and expressing human ERRα. As well, the invention relates to cell lines in which ERRα activity (and/or level) has been inactivated or augmented. The invention further relates to uses and methods of the transgenic animals of the present invention to select agents which modulate the expression and/or activity of ERRα, in particular in relation to fatty acid metabolism. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0122988-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7186879-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7193125-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02068386-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005003766-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1330645-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1330645-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005003766-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02068386-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1548434-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1548434-A4 |
priorityDate |
1999-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |