| abstract |
The invention relates to the novel epothilon derivatives of general formula (I) wherein R<4> is hydrogen, C1-C10 alkyl, aryl, C7-C20 aralkyl, R<5> is hydrogen, C1-C10 alkyl, aryl, C7-C20 aralkyl, R<6>, R<7> are each a hydrogen atom, or together an additional bond or an oxygen atom, R<8> is a methyl group or hydrogen, and simultaneously R<1a> and R<1b> together represent a trimethylene group and X is a 2-pyridyl, 2-methyl-4-thiazolyl or 2-methyl-4-oxazolyl residue or simultaneously R<1a> and R<1b> together represent a trimethylene group, R<2> is a methyl, ethyl or propyl group and X is a 2-pyridyl, 2-methyl-4-thiazolyl or 2-methyl-4-oxazolyl residue or simultaneously R<1a> and R<1b> each represents a methyl group, R<2> is a methyl, ethyl or propyl residue and X is a 2-pyridyl, 2-methyl-4-thiazolyl or 2-methyl-4-oxazolyl residue, wherein the nitrogen and/or sulfur atom in X can be present in oxidized form and, if R<2> and R<8> each means a methyl residue, X can only be a 2-pyridyl residue which is optionally oxidized at the nitrogen atom, including all possible stereoisomers and their mixtures. The novel compounds are useful for producing medicaments. |