| abstract |
The invention is directed to methods for stimulating angiogenesis by in vivo intramuscular, intradermal, and/or subcutaneous administration of cationic lipid-nucleic acid complexes. By inducing angiogenesis, these compositions are used to treat ischemia, including diseases which cause or result in insufficient circulation to and perfusion of tissues, such as peripheral vascular disease (e.g., as in diabetes, atherosclerosis) and coronary artery disease. |