| abstract |
Cinnamamide derivatives represented by general formula (I); and immunomodulators and preventive and therapeutic agents for nephrotic syndrome, circulatory disturbance and respiratory diseases, containing the same, wherein R1 is hydroxyl, C¿1?-C6 alkoxy, arylalkoxy or (substituted) amino; R?2 and R3¿ are each halogeno or C¿1?-C4 alkyl; R?4¿ is hydrogen or C¿1?-C6 alkyl; R?5¿ is hydrogen, C¿1?-C6 alkyl or aryl; R?6¿ is hydrogen, C¿1?-C6 alkyl, cyano or C1-C6 alkoxycarbonyl; W is O, S, imino, methylene, hydroxymethylene or carbonyl; X and Y are each O or S; m is an integer of 0 to 2; and n is an integer of 1 to 3, or alternatively the -C(R?2)(R3¿)-W- group may be vinylene when m is 0. |