| abstract |
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R7)- wherein R7 is hydrogen, hydroxy, C¿1-7?alkoxy, -OR?8 or -NR8R9¿ (wherein R8 is a group -Y1R10 (wherein Y1 is a direct bond, -C(O)-, -C(S)-, -S-, -C(O)O, -C(O)NR11-, -SO¿2?- or -SO2NR?12¿- (wherein R?11 and R12¿, which may be the same or different, each independently represents hydrogen, C¿1-3?alkyl or C1-3alkoxyC2-3alkyl) and R?10¿ is as defined herein, and R9 includes hydrogen; R?1, R2 and R3¿ are as defined herein and are preferably methyl; R?4, R5 and R6¿ are as defined herein with the proviso that R5 is not hydroxy, alkoxy, substituted alkoxy, -OPO¿3?H2, -O-C1-7alkanoyl or benzyloxy; and salts thereof in the manufacture of a medicament for use in the production of a vascular damaging effect in warm-blooded animals such as humans. The present invention further relates to compounds of the formula (I), pharmaceutical compositions containing them, processes for their preparation and to a method of treatment using the compounds to produce a vascular damaging effect in a warm-blooded animal such as a human. The compounds of formula (I) and the pharmaceutically acceptable salts thereof may be useful in the treatment of a number of disease states including cancer and rheumatoid arthritis. |