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filingDate 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-0038657-A1
titleOfInvention Method for preparing an effervescent granulate comprising iron gluconate, granulate thus obtained and tablets containing the same
abstract A method for preparing an effervescent granulate comprising ferrous gluconate as pharmacologically active ingredient, and citric acid and sodium bicarbonate as effervescent system, by means of wet granulation in a fluid-bed granulator, wherein the said method comprises the steps of I) feeding a mixture comprising ferrous gluconate, citric acid and sodium bicarbonate into the said granulator which is simultaneously fed with a flow of air heated to about 70 °C and having a moisture content of ∫1.0 g/kg; II) wetting the said mixture with nebulized water when this mixture has reached a temperature of about 35 °C; III) evaporating off the nebulizing water, while keeping the temperature of the said mixture substantially constant at 35 °C; IV) repeating steps II and III until a granulate with the desired features is obtained; and V) drying the said granulate with air heated to about 80 °C until its moisture content is ≤0.5 % by weight. Granulate thus obtained and tablets containing the same.
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