| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15be2d692680a5a0791245463ef2411c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7713f678bc7483f9fcad3417ca44b47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea76b1232c083cb030600f132143640b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da5c8e8c3e8261efe7e698c7198681b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571a06b94c407ebd37d3dbd82073a01d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f752ceae32ee1059973daad9681a5832
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f5fb461b03fc40d45eb69157b16faab |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
1999-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b364a617d80b0188142cbb77fb4455a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_637b87da5fab755bb6bc023ec18401ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3956c47c6acaaba159ec95c949216e72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7452b4cd629a2e54ef8eb82bae3dd829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b70b1f4b8388567c48a113bb268c47b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22fb5d2e4387a791016430c49a0d07d5 |
| publicationDate |
2000-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0037498-A1 |
| titleOfInvention |
THE POLYPEPTIDE DREAM, USED AS Ca2+IONS-DEPENDENT TRANSCRIPTIONAL REGULATOR AND ITS GENE CODING THEREFOR |
| abstract |
The DREAM suppression of the genic expression depending on DRE (c-jun and c-fos between two forms of DREAM (EFmutDREAM and LVmutDREAM) escape from the blocking by Ca2+ and by others) is regulated by Ca2+ and by the protein αCREM. Mutant forms αCREM respectively enable to define new strategies for the therapeutic control of pathologic process of oncologic type, troubles of apprenticeship, etc. On the other hand, DREAM is a target protein for the identification of new therapeutic compounds. Furthermore, the mutant forms in the regions of EF-hands of DREAM (EFmutDREAM) block the activities of CRE-dependent proteins and can be used in the regulation of the expression of these genes. CREB and CREM are involved in the final activation of a multiplicity of genes. |
| priorityDate |
1998-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |