| abstract |
Compounds represented by general formula (I) or salts thereof, giving drug compositions particularly suitable for oral administration which are useful in the treatment and prevention of β3-related diseases including diabetes, obesity and hyperlipidemia: in said formula R1 is hydrogen, methyl or SO¿2R?3; R2 is O, S or H¿2; R?2' is O or H¿2; R?3 is lower alkyl or NR?4R4'; R4 and R4'¿ are each independently hydrogen, lower alkyl or benzyl; R5 is hydrogen or lower alkyl; k and m are each 0 or 1; and A is a group represented by general formula, (II) or (III): (wherein X¿1? is secondary nitrogen, oxygen, sulfur or methylene; n is 1 or 2; X2 is secondary nitrogen, oxygen or sulfur; and R?6, R7 and R8¿ are each hydrogen or the like). |