| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_153a26fac192768f3a558c09f950a1af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45836f1ea39d23b52dccad40a499568f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9fbfeba067df93dd1d2b4417267540f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-141111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C281-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-36 |
| filingDate |
1999-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df0f1cbc19fa42f93f02283305331b91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3573f7e9a997236919d2ffb613b1fec |
| publicationDate |
2000-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0035868-A2 |
| titleOfInvention |
Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives |
| abstract |
Methods for the synthesis of α-hydroxy-β-amino acid and amide derivatives and α-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting an N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-α-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl α-ketoamides and α-hydroxy-β-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835392-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8273781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007140471-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005009784-B4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006092326-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006092326-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007140471-A3 |
| priorityDate |
1998-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |