| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_060ff17d3f463ad4bdb2a95cd9abb4e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee05d5c4374979bdb645833323f1529e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_509973426be22faee6b25bf8cc795741
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d385ec863ef8c79eafa6bad345da60e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59ec415f35cc409eb35071c37df297fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28ecb9d2655209cb54a6fcae204d4cba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-62 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate |
1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eafc65610632ab71f9d60f900259260
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8670affe6e4e470383258a91b5aea1f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db04240120d89782eee3be3913e98b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_606d8f6fc6298cda660a3cae8f639001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8e31b0c0a86b22b3cb6c768b02384e |
| publicationDate |
2000-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0031291-A1 |
| titleOfInvention |
Method for screening for substances which are activators, inhibitors or binders of pkb by the use of a substrate peptide and the use of the substrate peptide |
| abstract |
The invention relates to a method for screening for substances which are activators or inhibitors of Protein kinase B (PKB) and can be used as a kinase substrate for PKB. The substrate is a peptide comprising the two sequences R-R-R-A-A/V-S-M and R-P/S-R-S/T-S/N-S-N and preferably comprising the three sequences R-P-R-S-C-T-W, R-R-R-A-A/V-S-M and R-P/S-R-S/T-S/N-S-N. These sequences as well as the human Afx, amino acids 12-505 or amino acids 1-505, can be used in assays measuring the activity of PKB, and in screening for substances which are activators or inhibitors of gene transcriptional regulation of forkhead proteins through the catalytic activities of PKB. These sequences can also be used for discrimination between the effects of compounds which mediate insulin action through transcription from those which modulate activity of enzymes involved in metabolism by phosphorylation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013152041-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005007687-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7195884-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1583836-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1583836-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7314729-B2 |
| priorityDate |
1998-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |