| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb69fd820591a28cffd8dd1abdb380e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e95d0b7171a567a843bd777d0e575cda
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2fd2184696a88e9fcd64440642dca5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5f3323808948f7560df853448bb6ce7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16622 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
1999-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc5c910bc797e9f89c4d7f940676153d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dc6b10d7d1f5627c1b2ac7867266e36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3445c25412927b623361e2785f707c33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1b8528ede2c95a2a8a955de5bb8264b |
| publicationDate |
2000-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0028011-A2 |
| titleOfInvention |
Fk506-based regulation of biological events |
| abstract |
This invention provides methods and materials for making and using genetically engineered cells which are responsive to the presence of an FKBP/CAB ligand or a cyclophilin/CAB ligand. The invention relies upon the introduction into cells of recombinant DNAs encoding fusion proteins which are capable of forming a complex with each other in the presence of ligand. One of the fusion proteins contains a calcineurin A/calcineurin B domain (CAB) and at least one heterologous protein domain. The second fusion protein contains a domain derived from an FKBP protein which is capable of binding to an FKBP/CAB ligand and forming a complex with a CAB-containing protein. The second fusion protein may alternatively contain a cyclophilin domain which is capable of binding cyclosporin or other cyclophilin/CAB ligand and forming a complex with a CAB-containing protein. The second fusion protein also contains at least one heterologous domain. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7928057-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007085455-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105785027-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7094757-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7244819-B2 |
| priorityDate |
1998-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |