| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b87af5ccc4ad6883beca5891260d11da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d129195d35f178edd75fb75e7d8f5fd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-41 |
| filingDate |
1999-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5827751d7b34bd4c95dd691edbd49518 |
| publicationDate |
2000-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0027423-A2 |
| titleOfInvention |
Methods and compositions for treating common cold symptoms |
| abstract |
The present invention provides methods of inhibiting replication of cold-causing viruses in respiratory epithelium cells and elaboration of IL-8 in the cells of subjects exposed to the viruses, by interfering with the virus binding to the cell membrane receptor that stimulates elaboration of IL-8 and viral replication. A polypeptide that binds to a virus and interferes with the binding of the virus to the cell is provided. An antibody that binds to a cell membrane-bound cytochrome and interferes with the virus binding to the cytochrome is also provided. Further, a chemical inhibitor of a membrane-bound cytochrome, that inhibitis viral replication in and elaboration of IL-8 by the cell, is provided. Moreover, the present invention provides methods of treating and reducing cold symptoms in a subject comprising administering to a subject any of the compositions of this invention. Further, the invention provides methods of screening for a compound which inhibits the interaction of a cold-causing virus and a respiratory epithelium cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0224217-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114796189-A |
| priorityDate |
1998-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |