http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0024938-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3ef1355fca8bba415e2504351d0f304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3fe5734a55b42d359ce09a4faa6558a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e391686e094371a5c1b00f449c279be http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f5b170b7deeafcf11e6b95bac7d9291 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate | 1999-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bd38fb3c76058ad22e6d2c876c7031c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8e05b0be4683036fb14a8b286cfd9cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34f5df5bc979d0d78a7de7de1ea5045c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_179a55ba41a7d3b6779eddab908e82d6 |
| publicationDate | 2000-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0024938-A2 |
| titleOfInvention | CCG REPEATS IN cDNAs FROM HUMAN BRAIN |
| abstract | Expansion mutations of trinucleotide repeats and other units of unstable DNA have been proposed to account for at least some of the genetic susceptibility to a number of neuropsychiatric disorders, including bipolar affective disorder, schizophrenia, autism, and panic disorder. To generate additional candidate genes for these and other disorders, cDNA libraries from humain brain were probed at high stringency for clones containing CCG, CGC, GCC, CGG, GCG, and GGC repeats (referred to collectively as CCG repeats). 18 cDNAs containing previously unpublished or uncharacterized repeats were characterized for chromosomal locus, repeat length polymorphism, and similarity to genes of known function. The cDNAs were also compared to the 37 human genes in GenBank with eight or more consecutive CCG triplets. The repeats were mapped to a number of loci, including 1p34, 2p11.2, 2q30-32, 3p21, 3p22, 4q35, 6q22, 7qter, 13p13, 17q24, 18p11, 19p13.3, 20q12, 20q13.3 and 22q12. Length polymorphism was detected in 50 % of the repects. The newly cloned cDNAs include a complete transcript of human neurexin 1B, a portion of BCNG-1 (a newly described brain-specific ion channel), a previously unreported polymorphic repeat located in the 5' UTR region of the guanine nucleotide-binding protein (G-protein)β2 subunit, and a human version of the mouse proline rich protein 7. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9611508-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9777406-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9765387-B2 |
| priorityDate | 1998-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 558.