| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
1999-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_496ab611e18c1efc8cec809c31819444
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_707ca7876af808fa24b0fef843220a3c |
| publicationDate |
2000-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0024871-A2 |
| titleOfInvention |
Kv BETA 1.1-DEFICIENT MICE WITH IMPAIRED LEARNING |
| abstract |
This invention pertains to the discovery that a mutation disabling the Kvβ1.1 subunit of a A-type K+ channel decreases the slow afterhyperpolarization (sAHP) of hippocampal CA1 neurons and improves learning and memory in hippocampus-dependent tasks: Importantly, young mutants do not show this improvement indicating that the inihibition of Kvβ1.1 mediates the effects of age-related loss of learning ability and memory. Thus, in one embodiment this invention provides assays for modulators of Kvβ1.1. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03012041-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03012041-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110150194-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110150194-B |
| priorityDate |
1998-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |