| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c43dc21a4c705f61aa656f54b0e5134
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4335cade4fe0fc48b0a6e929e70d2e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3c9fc3cb0028234aedb8df651f9d2e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2316065123ab436a1f6f4eebc5ff4ad |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
1999-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_484e78c711dd4293e1684625edbda4e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eed31d2193f0383484909e8fe94112c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4214aebc62511f95b04c960981ebfd26 |
| publicationDate |
2000-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0024254-A1 |
| titleOfInvention |
Compositions and methods for modulating expression within smooth muscle cells |
| abstract |
The present invention relates to promoters, enhancers and other regulatory elements that direct expression within SMC, comprising nucleotide sequences from the 5' regulatory region and the first intron, and transcriptionally active fragments thereof, that control expression of an SM α-A. Specifically provided are expression vectors, host cells and transgenic animals wherein an SM α-A regulatory region is capable of controlling expression of a heterologous gene, over-expressing an endogenous SMC gene or an inhibitor of a pathological process or knocking out expression of a specific gene believed to be important for an SM-related disease in SMC. The invention also relates to methods for using said vectors, cells and animals for screening candidate molecules for agonists and antagonists of disorders involving SMC. The invention further relates to compositions and methods for modulating expression of compounds within SMC, and to screening compounds that modulate expression within SMC. Methods for using the molecules and compounds identified by the screening assays for therapeutic treatments also are provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9023823-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0204509-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1172375-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006107826-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1379643-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1379643-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006107826-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8592384-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0204509-A2 |
| priorityDate |
1998-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |