| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate |
1998-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87870e48b35802124b14da44732ae298
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50b558ccac1d5edc57a6cc07d149e17b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b9bb3deb54d939c4ff4f239af4f354f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aa574c31700400e26662ef45e4d129c |
| publicationDate |
2000-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0018234-A1 |
| titleOfInvention |
Thiazolidenediones alone or in combination with other therapeutic agents for tumor therapy |
| abstract |
A purpose of the present invention is to identify and/or develop nontoxic or low toxic chemotherapeutic regiments to treat cancer. Prototype cells tested are derived from an osteosarcoma from an eleven year girl who died after aggressive chemotherapeutic treatment with adriamycin, vincristine, cytoxan, and aramycin-C. The inventive steps described herein include demonstrating that troglitazone inhibits cell proliferation in human osteosarcoma cells, the presence of functional PPAR-η in such cells, and the demonstration of the ability of troglitazone to lower the IC50 of other chemotherapeutic agents such as 5-fluorouracil and doxorubicin when administered in combination therewith as regarding cell proliferation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004045611-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007144679-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7323481-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7045523-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007144679-A2 |
| priorityDate |
1998-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |