| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_54efcb0abb972c5cd5c387614a2fad10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b81cb00d46e57ece8758234aca4b0589 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
1999-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da44e3483a082679eaed5d6b274095d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c69cb8cf488bbcf45f2eb0da436bf0f |
| publicationDate |
2000-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0015783-A2 |
| titleOfInvention |
ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS TARGETED TO β1-ADRENOCEPTOR-SPECIFIC mRNA AND METHODS OF USE |
| abstract |
Disclosed are antisense oligonucleotides specific for mammalian mRNA encoding β1-adrenoceptor polypeptides that are useful in the control of hypertension and cardiovascular disease in a mammal. These oligonucleotide compositions provide sustained control of β1-adrenoceptor expression over prolonged periods, and achieve therapeutic effects from a single dose. Administration of these antisense compositions to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Use of such antisense compositions in the reduction of β1-adrenoceptor polypeptides in a host cell expressing β¿1-adrenoceptor-specific mRNA, and in the preparation of medicaments for treating human and animal diseases, and in particular, hypertension and other cardiac dysfunction is also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0204623-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0204623-A3 |
| priorityDate |
1998-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |