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filingDate 1999-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-0015767-A2
titleOfInvention Antigen-presenting cells and their use in therapy
abstract A method for ex vivo treatment of antigen presenting cells, wherein said method consists of in vitro culture of antigen presenting cells under conditions resulting in development of tolerogenic antigen presenting cells, such tolerogenic cells being characterised by: a) reduced induction of T cell activation upon T-cell receptor ligation as can be determined by any of the measurements selected from the group measurement of proliferation, measurement of cytokine production, measurement of cytotoxicity and measurement of expression of activation cell surface markers, b) a dominant tolerogenic effect. Also part of the invention are such tolerogenic antigen-presenting cells and artificial analogues, compositions containing them and their use in immunotherapy.
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