abstract |
Method for the preparation of citalopram comprising reaction of a compound of Formula (IV) wherein R is halogen, or CF3-(CF2)n-SO2-, n being 0 to 8, with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cu?+ or Zn2+¿, or with Zn(CN)¿2? in the presence of a palladium catalyst. |