| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a9105f2abe4c7598efd70690cd09903
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_893e97d370140a81a00b0b681dd438e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_224119dfe0b8aa602bb7d82f3bf70a15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8859fc4e16c4837b6febcfffd5685a33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_baeb0630b86b7c8b39ba39891e667030 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2291-02854 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01S15-8956
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B8-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01S7-52036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N29-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N29-0672
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01S15-895 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B8-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01S7-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N29-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01S15-89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N29-46 |
| filingDate |
1999-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d77d8023385bf7bc3267e4049af7bb8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6c29417c9d921e77759e9d49b6623d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96c81fc125e8c6529bc6e5071623a7ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1c2069f74239c9b7d7d92739301aa7b |
| publicationDate |
2000-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0011468-A2 |
| titleOfInvention |
The use of high frequency ultrasound imaging to detect and monitor the process of apoptosisin living tissues |
| abstract |
A non-invasive method of monitoring apoptosis in cell culture, ex-vivo tissues and in-vivo tissues using high frequency ultrasound imaging is provided. The method includes the steps of: 1) imaging a selected site of the cell culture or tissues using high frequency (above 20 MHz) ultrasound imaging (before image); 2) exposing the selected site to an apoptosis-inducing stress; 3) imaging the selected site or a portion thereof, using ultrasound imaging at subsequent timed intervals (after image(s)); 4) measuring the signal amplitude of a region of interest of the selected site in the before and after images; 5) comparing the signal amplitude measurements for the regions of interest in the before and after images and determining whether the after image regions exhibit an increase in amplitude as compared to the before image regions which is an indication that apoptosis has begun; and 6) measuring the change in the frequency spectrum of the radiofrequency ultrasound backscatter signal in the region of interest in the before and after images and confirming that apoptosis has begun when the slope of the frequency spectrum has increased. |
| priorityDate |
1998-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |