| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d595ec481a2a081fed4aa2fd4ff52d8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
1999-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa21f2f13bcd115d96b667f7099dd4a3 |
| publicationDate |
2000-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0010389-A1 |
| titleOfInvention |
BLOCKADE OF GLUCOSE TOXICITY TO THE β CELLS IN THE ISLETS OF LANGERHANS |
| abstract |
The present invention demonstrates that streptozotocin (STZ) is a specific toxin for the pancreatic β cells and that STZ specifically inhibits the activity of O-GlcNAc-selective N-acetyl-β-D-glucosaminidase (O-GlcNAcase), therefore, blocks O-linked N-acetylglucosamine (O-GlcNAc) removal from intracellular proteins. The present invention is also directed to a transgenic animal with impaired glucosamine synthesis and various methods of treating diabetes and of screening for drugs for treating diabetes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1456650-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1456650-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112891540-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02099083-A2 |
| priorityDate |
1998-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |