| abstract |
Compounds represented by general formula (1), prodrugs thereof or pharmaceutically acceptable salts of the same which are useful as remedies for hyperlipemia and arteriosclerosis because of having an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory effect, wherein the ring A represents an optionally substituted pyridine ring; Y represents optionally substituted alkyl, etc.; R1 represents hydrogen, optionally substituted alkyl, etc.; R2 represents hydrogen or lower alkyl; R3 represents lower alkyl; and Z represents: 1) -D1-Q (wherein D1 represents a bond, divalent C¿1-8? hydrocarbyl, etc.; and Q represents hydroxy, carboxy, etc.; or 2) -D?2¿-M-E-W (wherein D2 represents a bond, a divalent C¿1-8? hydrocarbyl, etc.; M represents oxygen, sulfur, etc.; E represents a bond, divalent C1-8 hydrocarbyl, etc.; and W represents hydroxy, carboxy, etc. |