| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9ef1cc964e25a6ecbb223017c4d02d7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1818 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-055 |
| filingDate |
1999-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48220a007ff1a3c7f3bc5d24aacb8d00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02b49bf6fab98d51b22073eca3f932d5 |
| publicationDate |
2000-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0009170-A1 |
| titleOfInvention |
Combination of a positive mri contrast agent with a negative mri contrast agent |
| abstract |
A first object of the invention is to provide administrable dual MRI contrast enhancing compositions containing as key components, at least (a) one positive paramagnetic metal chelate contrast agent and at least (b) one negative ferromagnetic or superparamagnetic contrast agent. These compositions distinguish the prior art by the properties of the said components toward the cell membrane barrier. Actually, either one of (a) and (b) predominantly internaliyes tissue, whereas the remaining one is predominantly retained in the circulation, this being for a time sufficient to provide shart MRI images of the circulation in said tissue. Typically, either one of (a) and (b) is predominantly intra-vascular while the other one is predominantly extra-vascular or is rapidly removed from the circulation by macrophages. Then, after removal from circulation it internalizes neighboring tissue. The transfer from vessels to tissues is effected by RES mediated phagocytosis. Alternatively, an extravascular compound may cross the vessel walls and distribute randomly extracellularly. Another object of the invention is to provide is to provide a dual blood pool contrast medium comprising a positive MRI contrast agent (a) mainly shortening the T1 relaxation response and a negative contrast agent (b) mainly shortening the T2 relaxation response, both relaxation effects of (a) and (b) being controllable at will. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7412279-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101142730-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014037498-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014037498-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101094207-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010021519-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115350336-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108430520-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265398-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10039843-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017079535-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11623007-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010021519-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010107178-A3 |
| priorityDate |
1998-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |