| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb36d1d80ca429e62a40eeaf5998fe6b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4cdf984e52e386742b6ba53f2672f7d3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-49 |
| filingDate |
1999-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d40ccc0720814ca69df6b3d2aef20453 |
| publicationDate |
2000-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0008167-A1 |
| titleOfInvention |
Trimer of hiv env gene expression product |
| abstract |
The invention concerns a purified recombinant glycoprotein having the following properties: a) an adherence capacity to CD4; b) an affinity with a anti-gp120 antibody capable of neutralising in vitro HIV cell infection; c) an affinity with an anti-gp41 antibody; d) a trimeric form free from inter-chain disulphide bonds. The invention also concerns a vaccine comprising said purified glycoprotein and an adjuvant. The invention further concerns a method for obtaining said glycoprotein as per Claim 1, which consists in expressing, by means of genetic recombining techniques, a glycoprotein corresponding to the properties a), b) and c) mentioned in Claim 1; purifying it, and subjecting it to steps involving at least a reducing agent, an ionic detergent and/or a neutral detergent in conditions leading to a glycoprotein having said properties. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6821723-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7056519-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03042388-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6861253-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2830534-A1 |
| priorityDate |
1998-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |