| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8823c2b4f1248d1e1da57b6a19bb1615
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78be35dbb736ca67d30b1bfc35c210cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5d5eb6f74b0f4dd6e8417e800498c5a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-48 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0793 |
| filingDate |
1998-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf1192342303b9c7eafc082733cd2fed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce4fededdacceda288f9e8faf55ec44e |
| publicationDate |
2000-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0006700-A1 |
| titleOfInvention |
Production and use of dopaminergic cells to treat dopaminergic deficiencies |
| abstract |
Differentiated neuronal cells suitable for transplantation in individuals with a dopamine deficiency are derived from progenitor cells. The progenitor cells are treated with at least one inducing agent such as retinoic acid for a time period sufficient to optimize expression of tyrosine hydroxylase. The cells intended for transplantation are optionally treated with a lithium salt to enhance bcl-2 production and survival. Optionally, the progenitor cells may be co-cultured with Sertoli cells, astrocytes, glial cells, accessory cells or a combination thereof. The transplantation-ready cells are isolated and harvested. The resulting neuronal cells are highly purified and have a phenotype optimized for a dopaminergic deficiency, such as Parkinson's Disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8232052-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008055224-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10493109-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067161-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9994816-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9453840-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004065599-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006009241-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8852938-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807371-B2 |
| priorityDate |
1998-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |