| abstract |
The invention relates to a compression-fluidized propellant mixture for aerosols, containing dinitrogen monoxide and a hydrofluoroalkane with between 1 and 3 carbon atoms, especially 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, which improves the wetting properties for pharmaceutical active ingredients so that the difficulties associated with the use of hydrofluoroalkanes in the preparation of suspension and solution aerosols can be overcome and improved medicinal aerosol formulations can be obtained as a result. Using dinitrogen monoxide it is also possible to influence pressure and thus particle size distribution in a targeted manner and to improve the stability at storage of oxidation-sensitive active ingredients by displacement of oxygen out of the hydrofluoroalkanes. If desired the propellant mixture can also contain carbon dioxide. |