| abstract |
There is disclosed a method for optimizing revascularizing ischemic tissue, particularly ischemic myocardial tissue. Specifically, there is disclosed a means for retrograde perfusion of angiogenic gene therapy vectors to ischemic tissue, wherein the polypeptide(s) encoded by the gene therapy vectors promote angiogenesis and neovascularization, and are selected from the group consisting of VEGF, ICAM-1, FGF, EGF, nitric acid synthase (NOS), E-selectin, and combinations thereof. |