| abstract |
The present invention provides a complex pharmaceutical formulation comprising a first mixture that includes amlodipine and chlorthalidone and a second mixture that includes losartan, which has improved dissolution and stability. The complex formulation according to the present invention can achieve improved preventive or therapeutic effects for cardiovascular diseases by operating different mechanisms of amlodipine, losartan and chlorthalidone, and shows high dissolution rates of amlodipine, losartan and chlorthalidone and improved storage stability, due to the Minimized drug interactions, and then, is useful in the fields of medications and medicine. |